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*                        warfarin_project.mlxtran                              *
*                        February 06, 2018 at 15:29:28                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)    pvalue
Tlag_pop                       :     0.902     0.161      17.9          
ka_pop                         :       1.7     0.448      26.3          
V_pop                          :      7.99     0.232       2.9          
beta_V_lw70                    :     0.868     0.148      17.1   4.8e-09
Cl_pop                         :     0.134   0.00641      4.76          
beta_Cl_lw70                   :     0.597     0.253      42.4    0.0183
Imax_pop                       :     0.998   0.00435     0.435          
IC50_pop                       :      1.15    0.0982      8.57          
kin_pop                        :      5.18     0.156      3.01          
kout_pop                       :    0.0535   0.00149      2.78          

Standard Deviation of the Random Effects -
omega_Tlag                     :     0.501     0.133      26.5          
omega_ka                       :     0.862      0.17      19.7          
omega_V                        :     0.145    0.0226      15.6          
omega_Cl                       :     0.263    0.0341        13          
omega_Imax                     :      1.32      8.06       610          
omega_IC50                     :     0.448    0.0631      14.1          
omega_kin                      :    0.0446    0.0242      54.1          
omega_kout                     :    0.0357    0.0248      69.6          

Error Model Parameters -------------------
a1                             :     0.273    0.0464        17          
b1                             :    0.0573    0.0092      16.1          

a2                             :      4.06     0.242      5.96          

Elapsed time (seconds) :       11
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Linearization --------------------------------------------------------
Correlation Matrix :
    Tlag_pop   1.00000
      ka_pop   0.20112   1.00000
       V_pop   0.06399   0.02605   1.00000
 beta_V_lw70   0.00486  -0.00676   0.11395   1.00000
      Cl_pop   0.02997  -0.02042   0.00271  -0.00001   1.00000
beta_Cl_lw70   0.00392   0.00245   0.00023   0.00151   0.08872   1.00000
    Imax_pop   0.18509   0.69531   0.00373  -0.01258  -0.00727   0.00519   1.00000
    IC50_pop   0.04450   0.14706   0.02357  -0.00229  -0.02796   0.00373   0.13975   1.00000
     kin_pop   0.09188  -0.08403   0.06838  -0.00732  -0.01655   0.00851  -0.18061  -0.01317   1.00000
    kout_pop   0.10300  -0.09635   0.07092  -0.00684  -0.01571   0.00865  -0.21861   0.01706   0.90813   1.00000
  omega_Tlag   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   1.00000
    omega_ka   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00471   1.00000
     omega_V   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00130  -0.00142   1.00000
    omega_Cl   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00105  -0.00034   0.00066   1.00000
  omega_Imax   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.05757  -0.51229   0.00250  -0.00010   1.00000
  omega_IC50   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00029  -0.00205  -0.00008  -0.00058  -0.01056   1.00000
   omega_kin   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00584  -0.00501   0.00119  -0.00012   0.02883   0.00528   1.00000
  omega_kout   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00652   0.00868  -0.00122   0.00013  -0.03669  -0.00741  -0.80687   1.00000
          a1   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00167   0.00189   0.00785  -0.01001   0.00750  -0.00750  -0.00138   0.00137   1.00000
          b1   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00642  -0.00248  -0.05571   0.00082  -0.02545   0.00290   0.00032  -0.00031  -0.79018   1.00000
          a2   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000   0.00000  -0.00408   0.00503  -0.00451  -0.00034  -0.06423  -0.03149  -0.05526  -0.04623  -0.00986   0.00320   1.00000
                               min       max   max/min
Eigen values           :      0.09       2.1        24

Elapsed time (seconds) :   0.065
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mode ---------------------------
             min        Q1    median        Q3       max
Tlag :     0.598     0.854     0.907     0.984      2.77
ka   :      0.33      1.65      1.82         2      3.64
V    :      5.05      6.96      8.09      8.87      12.3
Cl   :    0.0728      0.11     0.129     0.163     0.273
Imax :     0.998     0.998     0.998     0.998     0.998
IC50 :     0.527     0.813      1.18       1.6      2.42
kin  :      4.89      5.05      5.24      5.27      5.55
kout :    0.0517    0.0526    0.0531    0.0543    0.0564

Elapsed time (seconds) :       1
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